Genetic architecture of vitiligo and vitiligo subtypes, The
Vitiligo is an autoimmune disease that results in destruction of skin melanocytes and patches of white skin and hair. Family studies demonstrated a strong, but complex inherited basis for vitiligo. Subsequent genome-wide linkage and association studies identified over 50 vitiligo susceptibility loci, with most loci harboring genes involved in immune regulation, apoptosis, or melanocyte function. The identified loci fit together in a model of melanocyte-directed autoimmunity and suggest shared pathobiology between vitiligo and many other autoimmune diseases. In this work, I advance understanding ...
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