Intracellular and microglial immune response to flaviviral infection of the central nervous system, The
Flaviviruses cause the most cases of encephalitis in the world with the potential to cause significant morbidity and mortality. Of the Flaviviridae family, West Nile virus (WNV) and Japanese encephalitis virus (JEV) represent two of the most important pathogens that cause viral encephalitis. Understanding immune mechanisms responsible for ameliorating flaviviral infection of the central nervous system (CNS) is critical for understanding flaviviral pathogenesis. I have found that components of the Rig-I-like RNA helicase (RLR) pathway contribute to the control of JEV. I have demonstrated that ...
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