Signaling regulation of myelinating cells in the central nervous system
Oligodendrocytes produce an immense quantity of polarized membrane, myelin, that ensheaths axons in the central nervous system. Myelin facilitates efficient communication and also provides metabolic and trophic support to axons. My studies show that the AKT/mTOR signaling pathway regulates oligodendrocyte differentiation and myelination through multiple mechanisms. Oligodendrocyte precursor cells (OPCs) undergo extensive cellular remodeling as they extend and retract filopodial-like processes while they proliferate and migrate. OPCs then differentiate and begin producing myelin. These processes ...
(For more, see "View full record.")