Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules
A hallmark of the adaptive immune system in jawed vertebrates is its ability to generate a diverse collection of antigen receptors with numerous specificities. Such diversity improves species fitness by affording individuals the ability to recognize and clear any invading pathogen they may encounter. Humoral adaptive immunity by B cells generates innumerable specificities directed against native and soluble antigens. On the other hand, αβ T cells in cell-mediated adaptive immunity bear antigen receptors (TCRs) that primarily only recognize peptide fragments associated with major histocompatibility ...
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