From models to mechanisms : the pathogenesis and treatment of enterovirus D68-induced acute flaccid myelitis
In an effort to understand the paralytic disease caused by enterovirus D68 (EV-D68), we have developed a novel neonatal mouse model of infection that recapitulates many of the features of EV-D68-associated acute flaccid myelitis (AFM) (Chapter II). We found that several contemporary (circa 2014) strains of EV-D68 have the capacity to specifically infect and kill motor neurons in mice, resulting in the development of permanent paralysis. Older strains of EV-D68 did not cause disease in our model, suggesting that the recently observed changes in the EV-D68 genome may have facilitated both the ...
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