Human maternal obesity in the development of nonalcoholic fatty liver disease in a germ-free mouse model : identifying the role of the infant gut microbiome
Maternal metabolism and obesity contribute significantly to the risk of obesity and non-alcoholic fatty liver disease (NAFLD) in the next generation, however the causal drivers of this relationship are currently unclear. Metabolic diseases in the pediatric population pose a unique challenge as the mechanisms driving their onset and progression are hypothesized to be the result of programming by early life exposures in addition to lifestyle factors. The earlier onset of obesity and NAFLD in the pediatric population is associated with a worse natural history and progression of these conditions ...
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