Nuclear receptor regulation of a luminal breast cancer stem cell population
Crosstalk between nuclear receptors is emerging as important in regulating breast cancer (BC) treatment response and progression. Estrogen receptor (ER), progesterone receptor (PR), and retinoic acid receptor (RARα) are all co-expressed in luminal subtype BCs that are generally associated with good prognosis. This is mainly due to the success of endocrine therapies targeting ER. However, eventual resistance to endocrine therapy is a long-standing clinical problem that affects ~30% of patients. About half of all luminal tumors contain subpopulations of ER negative cells that express cytokeratin ...
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