Characterizing MIR137HG variation and contribution to risk for schizophrenia
The MIR137HG gene encoding microRNA-137 (miR-137) is associated with risk for schizophrenia (SZ) through genetic and functional studies, however, the molecular mechanisms underlying risk remain unknown. Through this work we characterize MIR137HG genetic risk architecture and describe novel regulatory mechanisms that contribute to neurodevelopment and potential etiology for SZ. Case-control haplotype analyses revealed novel MIR137HG common and rare haplotype associations. Multiple genetic variants contribute to these diagnostic associations including a nearby variable number tandem repeat (VNTR) ...
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