Mechanisms of immunoglobulin somatic hypermutation during retroviral infection
A potential HIV-1 vaccine should stimulate a broadly neutralizing antibody (bNAb) response, which overcomes HIV-1 mutational escape to typical NAb responses that develop by covering a wide variety of HIV-1 strains. bNAbs have been shown to both be highly mutated as well as contain essential mutations in framework regions (FWRs) of the immunoglobulin (Ig) variable domain. The typical mutator of Ig genes, AID, preferentially targets WRCY hotspot motifs, which are enriched in Complementary Determining Regions (CDRs) of Ig genes but underrepresented in FWRs. An evolutionarily related group of ...
(For more, see "View full record.")