Developmental origins and heterogeneity of the neocortical oligodendrocyte lineage
The formation of neocortical circuits during development requires coordinated production of excitatory projection neurons, astrocytes, and oligodendrocytes from a shared pool of neural progenitor cells. While we are beginning to understand the molecular mechanisms underlying the specification of neurons and astrocytes, far less is known about the developmental origins of the oligodendrocyte lineage and how oligodendrocytes are generated from neocortical progenitor cells. Considering the importance of oligodendrocytes for proper function of the neocortex, it is critical to understand the mechanisms ...
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