Centrosome number homeostasis : lessons from CEP135 isoform dysregulation in breast cancer
The centrosome, comprised of two centrioles surrounded by pericentriolar material, is the cell’s central microtubule organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate once in S phase. Loss of such coupling produces supernumerary centrosomes, a condition called centrosome amplification (CA). CA can promote hallmarks of tumorigenesis. In this thesis, I investigate the contribution of centriole overduplication to CA and its consequences on microtubule organization and genomic stability in breast cancer cells. CEP135, a centriole assembly protein, ...
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