Mechanisms that impact DNA-dependent activities of human mitochondrial transcription factor A
The mitochondrion is best known as the energy transducing organelle responsible for generating adenosine triphosphate that the cell requires for life. Transcription and compaction of the multicopy mitochondrial genome is performed by mitochondrial transcription factor A (TFAM). Unlike the nucleus, regulation of mitochondrial transcription and compaction is poorly understood. Recently varying levels of cytosine methylation (5mCpG) have been identified throughout the mitochondrial genome. These 5mCpG levels have correlations to altered mitochondrial RNA transcripts levels in several disease ...
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