Single cell RNA sequencing unravels unique molecular determinants of ER+ breast cancer organ-specific metastasis
Over half of all deaths from breast cancer are due to metastatic estrogen receptor positive (ER+) disease. Patients with ER+ breast cancer are at chronic and prolonged risk of relapse; overall survival upon detection of distal metastasis is less than 2 years. The most frequent sites of ER+ breast cancer metastasis are bone, liver, lung, and brain, with individual tumors metastasizing to one or more sites. The underlying mechanisms of site-specific metastasis are poorly understood and are critical for prevention and treatment of metastatic disease. A prevailing theory is that tumor cells seed ...
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