Pre-clinical assessment of memantine as a potential therapeutic agent for the treatment of Down Syndrome
Down syndrome (DS) is the most common genetically defined cause of intellectual disabilities and the Ts65Dn mouse is the most researched mouse model for DS. Three major alterations in hippocampal synaptic plasticity have been described in Ts65Dn mice: 1) reduced long-term potentiation (LTP) in the CA1; 2) almost complete absence of LTP in the dentate gyrus; and 3) increased long-term depression (LTD) in the CA1 region. At present, the mechanisms underlying these changes in synaptic plasticity are not well understood. However, there are several human chromosome 21 encoded proteins that are ...
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Scott-McKean, Jonah Jacob
Costa, Alberto C. S.; Vijayaraghavan, Sukumar
Access restricted until June 30, 2014.