Transcriptome signatures and signaling pathways in heart failure
Current heart failure treatment is based on targeting symptoms and left ventricle dysfunction severity, relying on a common HF pathway paradigm to justify common treatments for HF patients. This common strategy may belie an incomplete understanding of heterogeneous underlying mechanisms and could be a barrier to more precise treatments. We hypothesized we could use RNA-sequencing in human heart tissue to delineate HF etiology-specific and subphenotype-specific gene expression signatures. RNA-seq was performed in 64 human left ventricular samples: 37 dilated, 13 ischemic, and 14 non-failing. The ...
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