Regulation of central B cell selection by the ERK and PI3K signaling pathways
In some patients with autoimmune diseases, autoreactive B cells are able to bypass central tolerance mechanisms to escape into the periphery and promote disease. A better understanding of the molecular pathways that control central B cell selection is needed to establish how to impede the escape of these autoreactive B cells from the bone marrow. Basal B cell receptor (BCR) signaling plays a vital role in the central selection of immature B cells. ERK, a MAP Kinase, and Phosphoinositide-3-kinase (PI3K) are essential mediators of BCR signaling that are crucial for the differentiation of ...
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