Understanding structured-viral 3’UTR control of protein sysnthesis
In addition to the well-known 5’ cap and 3’ poly(A) tail, it is becoming increasingly clear that signals based on structured RNA elements within a messenger 3’ untranslated region (3’ UTR) can enhance translation in eukaryotes; these are poorly understood. To address this, I used a powerful model system from the turnip yellow mosaic virus (TYMV). The TYMV viral RNAs are 5’-capped but instead of a poly(A) tail, they terminate in a highly structured 3’ UTR that contains two structural domains: an upstream pseudoknot domain (UPD) and a tRNA-like structure (TLS). These domains work together to enhance ...
(For more, see "View full record.")