Nucleotide metabolism in Salmonella pathogenesis
Entereopathogenic Salmonella cause debilitating diseases in millions of people every year worldwide. As antibiotic treatments for Salmonella fail due to increased prevalence of antimicrobial resistance, generation of novel anti-Salmonella therapeutics becomes more pressing and will be aided by extensive knowledge of these bacteria. To that extent, we have discovered novel mechanisms by which Salmonella uses its nucleotide metabolism to empower its virulence. In Salmonella, the signaling nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], synthesized by RelA and SpoT, regulate ...
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