Investigating diverse roles of retinoic acid in the embryonic and adult brain
Retinoic acid (RA) is a member of the retinoid family of lipids and the active metabolite of vitamin A. Within the brain, its role as a neural differentiation factor and a regulator of synaptic plasticity is very well established. Excess and lack of Vitamin A or RA is associated with malformations in the developing brain as well as defects in higher cognitive functions in the adult brain. These abnormalities likely not only result from functional defects in neurons, but may be a consequence of an effect of RA on adjacent cell types other than neurons. How RA influences cell types other than ...
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