Regulation of cardiac fibrosis by class l histone deacetylases
Rationale: Pan-Histone Deacetylase (HDAC) inhibitors are efficacious in animal models of left ventricular (LV) heart failure; however, the specific enzymes and mechanism(s) of action are not well defined. Objective: These studies were completed using selective small molecule HDAC inhibitors to expose the mechanism(s) through which anti-fibrotic effects of HDAC inhibitors occur. Methods and Results: To elucidate the roles of specific HDAC isoforms, the relative ability of pan- and isoform-selective HDAC inhibitors to block cardiac fibrosis was assessed in the mouse angiotensin II (Ang II) ...
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Williams, Sarah Marie
Access restricted until December 31, 2013.