Eya3 threonine phosphatase promotes triple negative breast cancer growth through PD-L1 regulation of the tumor adaptive immune response, The
The Eya family of proteins are critical developmental transcription factors that are highly expressed in early embryogenesis where they promote cell survival, proliferation, migration and invasion. Most Eya proteins are downregulated after development is complete, but amplification and/or re-expression of Eya proteins occurs in many tumor types. In breast cancer, the Eya proteins regulate tumorigenesis and metastasis through their ability to act as transcriptional cofactors to the Six family of proteins and to act as tyrosine phosphatases. Intriguingly, Eya proteins contain a completely separate ...
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