Pre-ribosomal RNA is associated with sputum culture status in tuberculosis: proof-of-concept for a novel marker of treatment response
Tuberculosis (TB) is the leading cause of death from infection worldwide killing 1.4 million people in 2015. There is an urgent need for shorter TB treatment but a major impediment to TB drug trials is lack of early surrogate outcomes. Existing surrogate endpoints are cultured-base and poorly predictive of treatment failure and relapse. My thesis analyzed data from a proof-of-concept study of a novel molecular marker of treatment effect: the ratio of bacterial precursor-ribosomal RNA to total 23S rRNA (pre-rRNA/23S). Pre-rRNA/23S measures the rate of Mycobacterium tuberculosis (Mtb) replication ...
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