Immunological pathways controlling transplant tolerance and rejection
Organ, tissue, and cellular transplants annually save or enhance the lives of tens of thousands to millions of patients with severe diseases or debilitating injuries. However, grafts are vulnerable to immune-mediated rejection. An ideal alternative to treating recipients with toxic, life-long immunosuppressive therapies would be to administer transient regimens that achieve durable immune tolerance. Unfortunately, clinically relevant factors can block transplant tolerance induction, including peri-transplant inflammation and preexisting anti-donor immunity. In order to develop effective ...
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