Immunological pathways controlling transplant tolerance and rejection
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Organ, tissue, and cellular transplants annually save or enhance the lives of tens of thousands to millions of patients with severe diseases or debilitating injuries. However, grafts are vulnerable to immune-mediated rejection. An ideal alternative to treating recipients with toxic, life-long immunosuppressive therapies would be to administer transient regimens that achieve durable immune tolerance. Unfortunately, clinically relevant factors can block transplant tolerance induction, including peri-transplant inflammation and preexisting anti-donor immunity. In order to develop effective ...