Selection and implementation of non-linear mixed models in pharmacokinetic research: a NONMEM/PDx-pop tutorial for statisticians, The
Pharmacokinetic (PK) studies aim to develop models of the absorption, distribution, metabolism and excretion of a drug by the body. Traditional PK studies focus on minimizing inter-individual variability and obtaining initial understandings of the PK pathways, often through use of a sample of healthy subjects and strict study control protocols. In contrast, population-PK studies typically utilize a large sample from the population of interest and attempt to explain sources of variability including various demographic, genetic, or concomitant drug covariates. PK studies represent a significant ...