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    T cell trafficking and function changes during Type 1 diabetes progression

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    http://hdl.handle.net/10968/1917
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    Abstract
    Type 1 diabetes (T1D) is an autoimmune disease resulting from primarily T cell mediated destruction of pancreatic islet β-cells. To initiate β-cell destruction T cells must first be able to enter the islets. Changes in T cell entry into the islets at different stages of islet infiltration may give insight into mechanisms of disease progression. This work shows that at early stages of disease T cell entry into the islets is highly restrictive, but as infiltration progresses T cell entry becomes less restrictive. CD11c+ antigen presenting cells (APCs) are required for efficient T cell entry into ...
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    Author(s)
    Lindsay, Robin Sean

    Advisor(s)
    Friedman, Rachel S.

    Rights Access
    Embargo Expires: 05/26/2019

    Date Submitted
    2017
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    • Theses and Dissertations - School of Medicine

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