T cell trafficking and function changes during Type 1 diabetes progression
Type 1 diabetes (T1D) is an autoimmune disease resulting from primarily T cell mediated destruction of pancreatic islet β-cells. To initiate β-cell destruction T cells must first be able to enter the islets. Changes in T cell entry into the islets at different stages of islet infiltration may give insight into mechanisms of disease progression. This work shows that at early stages of disease T cell entry into the islets is highly restrictive, but as infiltration progresses T cell entry becomes less restrictive. CD11c+ antigen presenting cells (APCs) are required for efficient T cell entry into ...
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