Now showing items 1-6 of 6
Using optogenetics and biochemistry to uncover how autophagy regulates cell death
Author(s):Fitzwalter, Brent Eugene
Macroautophagy (autophagy) is intimately linked with cell death and often allows cancer cells to evade apoptosis. This has prompted clinical trials to combine autophagy inhibitors with other drugs with the aim of reducing ...
Use of a listeria monocytogenes protein to stimulate immune responses and anti-tumor effects
Author(s):Ortiz, Amber Leigh
Natural killer (NK) cells are a type of innate immune cell that secrete IFN when activated. IFN has pro-inflammatory effects and can act on tumor cells to kill them or inhibit their proliferation. NK cells can also exert ...
Collagen crosslinking and extracellular matrix remodeling in breast and pancreatic cancer
Author(s):Barrett, Alexander Steven
Much effort has been devoted to understanding the molecular mechanisms by which stromal remodeling contributes to solid tumor progression. The extracellular matrix (ECM) is a major component of the stroma that normally ...
Circulating tumor cells expansion and inactivation
Circulating tumor cells are cells that have shed from the primary tumor into the vasculature. They can be heterogeneous from the primary tumor as well as within the CTC population and are of prognostic value in metastatic ...
Somatic evolution in cancer
Author(s):Smith, Kyle Scott
Somatic mutations acquired through a lifetime have been shown to play driving roles in cancer development. Recent large-scale efforts by The Cancer Genome Atlas and other genome projects have identified the major oncogenic ...
Loss of EBF family transcription factor function drives leukemogenesis and impairs neuronal development
Early B cell factor (EBF) genes 1-4 encode a family of highly conserved transcriptional regulators that are differentially expressed across select tissues in both mammals and insects. Two of these proteins, EBF1 and EBF3, ...