Now showing items 1-8 of 8
Centrosome number homeostasis : lessons from CEP135 isoform dysregulation in breast cancer
Author(s):Ganapathi Sankaran, Divya
The centrosome, comprised of two centrioles surrounded by pericentriolar material, is the cell’s central microtubule organizing center. Centrosome duplication is coupled with the cell cycle such that centrosomes duplicate ...
Nuclear receptor regulation of a luminal breast cancer stem cell population
Crosstalk between nuclear receptors is emerging as important in regulating breast cancer (BC) treatment response and progression. Estrogen receptor (ER), progesterone receptor (PR), and retinoic acid receptor (RARα) are ...
Single cell RNA sequencing unravels unique molecular determinants of ER+ breast cancer organ-specific metastasis
Author(s):Padilla Just, Nuria
Over half of all deaths from breast cancer are due to metastatic estrogen receptor positive (ER+) disease. Patients with ER+ breast cancer are at chronic and prolonged risk of relapse; overall survival upon detection of ...
Eya3 threonine phosphatase promotes triple negative breast cancer growth through PD-L1 regulation of the tumor adaptive immune response, The
The Eya family of proteins are critical developmental transcription factors that are highly expressed in early embryogenesis where they promote cell survival, proliferation, migration and invasion. Most Eya proteins are ...
Tryptophan catabolizing enzyme TDO2 as an immunotherapeutic target in breast cancer, The
Tryptophan catabolism is an attractive target for reducing tumor progression and improving antitumor immunity in multiple cancers. In triple-negative breast cancer (TNBC), tumor infiltration by CD8 T cells correlates with ...
Tryptophan catabolism promotes triple-negative breast cancer metastasis
The studies in this dissertation were designed to explore potential therapeutic targets in triple-negative breast cancer (TNBC) based on genes expressed under anchorage independent conditions since TNBC has the worse ...
Mechanistic and a prognostic role for the ETS transcription factor ESE-1 in HER2+ breast cancer, A
The ETS transcription factor ESE-1/Elf3 controls transformation in human mammary epithelial cells although precise mechanisms by which this occurs and the breast cancer subtype(s) in which ESE-1 is most functionally relevant ...
Semaphorin 7A drives breast cancer progression through intrinsic and extrinsic mechanisms
Author(s):Tarullo, Sarah Elizabeth
Breast cancer (BC) remains the second leading cause of cancer-related deaths for women in the US—mainly due to metastatic disease. Additionally, women aged <45 who are within 5-10 years of most recent childbirth at BC ...