Now showing items 1-5 of 5
Precision therapeutic approach to autoimmunity caused by PI3K pathway dysregulation, A
Contributor:Franks, Sarah Elizabeth
GWAS and candidate studies have identified risk-conferring allelic variants that impair the ability to maintain immune tolerance. Several of these risk alleles are thought to function in B cell signaling, including negative ...
Professional APCs are involved in the recruitment and activation of T cells within the islets during Type 1 diabetes progression
Contributor:Sandor, Adam Miklos
Type 1 diabetes (T1D) is caused by the T cell mediated autoimmune destruction of the insulin-producing β cells within the pancreatic islets. Along with T cells, professional antigen presenting cells (APCs) are also required ...
Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and functionality of surviving CD8+ T cells
It is common practice for researchers to use antibodies to remove a specific cell type to infer its function. However, it is difficult to completely eliminate a cell type and there is often limited or no information as to ...
Role of ETV6 germline mutations in B cell development and predisposition to leukemia, The
Acute lymphoblastic leukemia is the most common cancer in children, and the tumor suppressor ETV6 has long been associated with the disease, most commonly as part of the ETV6-RUNX1 translocation. Our group and others ...
Regulation of central B cell selection by the ERK and PI3K signaling pathways
In some patients with autoimmune diseases, autoreactive B cells are able to bypass central tolerance mechanisms to escape into the periphery and promote disease. A better understanding of the molecular pathways that control ...