Role of follicular regulatory T cells in HIV and SIV pathogenesis, The
During chronic HIV infection, virus replication is concentrated in secondary lymphoid follicles, specifically in follicular helper T cells (TFH). The germinal center (GC) reaction is dysregulated during chronic HIV infection. Mechanisms underlying these phenomena have not yet been fully described. Follicular regulatory T cells (TFR) are a subset of T cells that are found in secondary lymphoid follicles, and have been shown to regulate TFH and GC dynamics. Whether TFR are more or less permissive than TFH is unknown. The effects of chronic HIV infection on the TFR function have not been investigated. ...
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