Viral and host determinants of Chikungunya virus persistence
Chikungunya virus (CHIKV) is a mosquito-transmitted arthritogenic alphavirus that is a global public health burden. In 2013, CHIKV spread from the Eastern Hemisphere to the Americas where it has since spread to 45 countries and territories in the region and caused nearly two million cases. CHIKV disease in humans is debilitating, and characterized by a sudden onset of high fever, severe joint pain and inflammation. More severe outcomes, including death, occur in neonates, the elderly, and in those with underlying medical co-morbidities. In many patients, disease signs and symptoms, including ...
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