Now showing items 1-10 of 13
Role of JMJD5 and JMJD6 in transcriptional pause release, The
30-60% of genes in higher eukaryotes are regulated by promoter-proximal pausing of Pol II, thus representing a major transcription regulatory mechanism. Previously, we reported that two orphan Jumonji C domain (JmjC)-containing ...
Biological implications of distinctive H3K79me2 patterns in acute myeloid leukemia
Author(s):Kingsley, Molly Christine
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are found in 20-30% of adult acute myeloid leukemia (AML). Wild type IDH1/2 produce a-ketoglutarate (aKG), an important co-factor for many enzymes including DNA, RNA, ...
Epigenetic and Co-transcriptional regulation of B lymphocyte development and function
B lymphocyte development and function are tightly regulated processes that are dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Several factors contribute to the ...
Transcriptome-wide investigation of nuclear RNA-binding proteins
RNA-binding proteins play a number of important roles throughout the cell. In order to more closely investigate their activity, we have adapted high-throughput techniques to characterize their activity across the transcriptome. ...
Unraveling novel functions of SIR complex in heterochromatic silencing
Author(s):Zukowski, Alexis Min
Cell differentiation requires regulated alterations in chromatin structure that result in changes in transcriptional activity and replication timing of the genome. Heterochromatin is a highly condensed and hypoacetylated ...
Regulation of MUC5B expression in idiopathic pulmonary fibrosis
Author(s):Helling, Britney Anna
Idiopathic pulmonary fibrosis (IPF) is the most common and the most aggressive fibrosing interstitial lung disease (ILD). Despite recent promising clinical trials, IPF remains incurable and largely untreatable. Genetic ...
Towards understanding the epigenetic contribution to neural development and neural tube defects in the mouse model system
Failure of embryonic neural tube closure results in the second most common class of birth defects known as neural tube defects (NTDs). While NTDs are likely the result of complex multigenic dysfunction, it is not known ...
Chromatin dynamics and genomic instability during replicative aging
Histones are the fundamental protein subunit of chromatin and have a profound impact on processes such as chromatin assembly/disassembly and diseases such as aging. I examined the functional importance of mutating the ...
Regulation of histone reader binding by histone post-translational modifications and multi-domain crosstalk
The accessibility of eukaryotic DNA depends on the compaction of chromatin, and ultimately on the position and dynamics of nucleosomes. The nucleosome undergoes a wide array of epigenetic modifications on DNA and histones ...
Epigenetic modifier KDM3A and its downstream target MCAM promote growth and metastasis in Ewing Sarcoma, The
Author(s):Lupo, Marybeth Sechler
This study aims to explore the roles and mechanisms of new candidates for therapeutic targeting in Ewing Sarcoma. Ewing Sarcoma is an aggressive pediatric malignancy of the bone and soft tissue, driven by EWS/Ets oncogenic ...