Allergic B cells are central to establishing murine peanut allergy in an adoptive transfer model but are not required for maintaining long-lived serum immunoglobulin E levels
Peanut allergy, characterized by elevated anti-peanut IgE levels that are typically lifelong, is a growing problem worldwide. The role B cell subsets play in maintaining long-lived serum anti-peanut IgE levels in peanut-allergic humans is unknown. We developed an adoptive transfer model of murine peanut allergy to investigate the role of B cells in establishing this immune response. We also independently treated peanut-allergic mice with anti-CD20 antibody or bortezomib to determine the role B cell subsets play in maintaining peanut allergy. Our results demonstrate that B cells with a memory ...
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