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    Expression, potency, and antiviral mechanisms of the interferon-alpha subtypes in retroviral infection

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    http://hdl.handle.net/10968/1132
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    Expression, potency, and antiviral mechanisms of the interferon-alpha subtypes in retroviral infection (8.999Mb)
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    Abstract
    More than 30 years after the first recognition of AIDS, HIV-1 infection remains an enormous public health burden globally. Understanding mechanisms of innate immunity to HIV-1 could fulfill the critical needs of novel antivirals, vaccines, or curative therapies. The Type I Interferons (IFN-I), in particular the IFN-alphas (IFN-α), are the first line of defense against HIV-1. The IFNA family in humans consists of 13 genes that all have a common receptor. The expansion of the IFNA family raises important evolutionary questions regarding their expression and potency against specific pathogens. While ...
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    Author(s)
    Harper, Michael S.

    Advisor(s)
    Santiago, Mario

    Rights Access
    Embargo Expires: 08/19/2016

    Date Submitted
    2015
    Collections
    • 2012 - 2016
    • Theses and Dissertations - School of Medicine

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