Mechanisms of NK cell-mediated injury in ischemia reperfusion injury in the kidney
Acute Kidney Injury (AKI) is a major concern in today’s healthcare system and is caused by various conditions such as trauma, major surgery, and sepsis. Regardless of causation, fifty percent of AKI cases are induced by ischemia, resulting in necrosis and apoptosis of nephrons, the functional units of the kidney. I employ a novel hanging weight model of AKI that, recapitulates the pathogenesis and clinical manifestations of ischemia reperfusion injury (IRI). Through these studies, we highlight NK cell activity and their direct contributions to damage in IRI of the kidney. NK cells are innate ...
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