SHIP-1 regulation of B lymphocyte signaling
Antigen receptor (BCR) signals direct fate, function and survival of B cells. These signals must be precisely regulated to generate a highly diverse BCR repertoire capable of mounting adaptive responses to pathogens, while simultaneously avoiding malignancy and autoimmunity. The inositol 5-phosphatase SHIP-1 has been established as a mediator of active inhibition of BCR signaling by co-aggregated FcɣRIIB. SHIP-1 converts PI(3,4,5)P₃ to PI(3,4)P₂, reducing recruitment of critical signaling intermediaries whose functions depend on plextrin homology domain-dependent association with plasma ...