Evaluation of 64Cu-ATSM in cell culture for potential use as a radiotherapy agent
Oxygen status of tumors is an important clinical factor when considering treatment and potential outcomes. In radiotherapy applications, hypoxic tumors display resistance to traditional low linear energy transfer (LET) external beam radiotherapy (EBRT), instigating interest in finding alternative and more effective means to treat these tumors. 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) has shown clinical usefulness in imaging and experimental radiotherapy of solid state tumors due to its ability to concentrate in hypoxic tissue regions and emit radiations of multiple types, energies, ...
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