Significance of ERα, HER2, and CAV1 expression and molecular subtype classification to canine mammary gland tumor
Date
2013
Authors
Shinoda, Hitomi, author
Hanneman, William H., advisor
Legare, Marie E., committee member
Mason, Gary L., committee member
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Abstract
Canine mammary gland tumor and human breast cancer share many similar features regarding their risk factors, histopathological features, and behavior. Despite the increasing evidence of molecular marker expression as a prognostic factor for human breast cancer, there are only little studies using this approach on canine mammary gland tumor. Our aim was to evaluate the significance of the expression of Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 to the behavior and the clinical outcome of canine mammary gland tumor by Immunohistochemistry. We also assessed the correlation between 5 subtype classification (Luminal A, Luminal B, HER2-overexpressing, Basal-like, and Normal-like) and tumor behavior and prognosis. Canine mammary gland tissues were stained for Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 and evaluated for the positivity, and classified into 5 subtypes according to the staining status. Although there was no statistical significance among the subtypes, the positivity of Nuclear Estrogen Receptor-alpha, Extranuclear Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 showed significant correlations (p<0.05) in the behavior and the prognosis of the tumor. This study indicates the prognostic value of immunohistochemistry staining status of Estrogen Receptor-alpha, Human Epidermal Growth Factor-2, and Caveolin-1 for canine mammary gland tumor. In addition, some trends were seen in 5 subtypes on the prognosis of the tumor, implying that although further analysis is needed, the potential application of 5 subtype classification to canine mammary gland tumor.
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Subject
molecular subtypes
estrogen receptor alpha
human epidermal growth factor receptor 2
human breast cancer
canine mammary gland tumor
Caveolin 1