Progress toward the total synthesis of citrinadins A and B
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In 2005 Kobayashi reported the isolation and absolute stereochemistry of Citrinadin A (1) and Citrinadin B (2), novel secondary metabolites of the marine fungus Penicillium citrinum. In addition to their interesting molecular architecture, the citrinadins are biologically active. Both exhibit cytotoxicity against murine leukemia L1210 (IC50 6.2 and 10 μg/mL respectively), and 1 has shown activity against human epidermoid carcinoma KB cells (IC50 6.2 μg/mL). Synthesis of 1 and 2 would allow for further testing of their biological activity and remains the best way to confirm their assigned ...