Plainsman Research Center at Walsh, Colorado, 2002
Kevin Larson shares the results of his research at a field day, August 29, 2002 at the Plainsman Research Center at Walsh, Colorado.The progression of leprosy disease highly correlates with predominant type 1/type 2 cytokines and proliferation of Th1/Th2 cells in response to M. leprae. Th1 immunity is thought to be protective to M. leprae infection but Th2 immunity is pathogenic. The primary objective of this dissertation was to identify and characterize a panel of new protein based T cell antigens, particularly those that induce Th1 immunity, in order to understand host-M. leprae interaction and to develop diagnostic tests for leprosy. Cellular mediated immunity (CMI) based in vitro interferon-γ released assay (IGRA) to M. ...