Synthetic approach towards cephalezomine A and phomoidride D
Two synthetic approaches towards cephalezomine A and phomoidride D are described separately. The first approach towards cephalezomine A invented a new method for the synthesis of 3-butoxy-1-chlorobutenone and successful constructed α-O and ß' -N disubstituted dienone for a designed key intermediate of cascade cyclization by Eschenmoser coupling of thiolactam and 3-butoxy-1-chlorobutenone. The second approach towards phomoidride D systematically studied the electronic effects of different ester substituents for the phenolic oxidation and inverse electron demand Diels-Alder reaction, which ...
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