Associations between common variants in FTO and near MC4R genes on BMI, waist circumference, and type 2 diabetes prevalence among Hispanic and non-Hispanic white individuals : the San Luis Valley diabetes study
Introduction: The prevalence of obesity and type 2 diabetes (T2D) has risen sharply in the United States over the previous 40 years. Heritability estimates for obesity are generally high, and suggest that people may have genotypes that predisposes them to obesity when confronted with an obesogenic environment. Genetic variants in FTO and near MC4R genes have consistently been shown to be associated with risk of obesity. Methods: Utilizing data from the third examination of the San Luis Valley Diabetes Study (1997-1998, n = 837), we determined the minor allele frequency (MAF) and genotype ...
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