A divergent synthesis of secologanin derived natural products
Date
2010
Authors
English, Brandon Joel, author
Williams, Robert M., advisor
Ferreira, Eric M., committee member
Eckstein, Torsten, committee member
Elliot, C. Michael, committee member
Finke, Richard G., committee member
Journal Title
Journal ISSN
Volume Title
Abstract
This dissertation documents the racemic total synthesis of the natural products oleocanthal, geissoschizol, corynantheidol, dihydrocorynantheol, protoemetinol, and 3-epi-protoemetinol from a single synthetic intermediate. Also described are efforts to produce an optically pure supply of the common synthetic intermediate of the above described natural products. The work described herein represents the first steps toward the development of a general strategy capable of synthesizing several structurally diverse members of the family of compounds derived from secologanin.
Description
Department Head: Ellen R. Fisher.
Rights Access
Subject
Secologanin
Biosynthesis
corynantheidol
Organic compounds -- Synthesis
oleocanthal
Enantiomers -- Biotechnology
geissoschizol
dihydrocorynantheol
protoemetinol