Studies toward the total synthesis of Fusarin C
Date
1996
Authors
Esslinger, Christopher Sean, author
Williams, Robert M., advisor
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Abstract
The development of the synthesis of the heterocyclic proposed pharmacaphore of the natural mutagenic fungal metabolite fusarin C is discussed with the result of a short and elegant synthesis for this portion of the molecule. The structural integrity of this compound was studied giving rise to a method of diastereomeric preference. Studies to further the synthesis of the natural product are discussed which result in successful alkylation of the heterocycle. The alkylation procedure then produced two new non-natural products which when tested for mutagenic activity along with the heterocycle, may provide information as to the function of the penta-ene side chain of fusarin C in regard to mutagenic activity.
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Subject
Fusarium
Pathogenic fungi
Organic compounds -- Synthesis