Methods for network generation and spectral feature selection: especially on gene expression data
Date
2019
Authors
Mankovich, Nathan, author
Kirby, Michael, advisor
Anderson, Charles, committee member
Peterson, Chris, committee member
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Abstract
Feature selection is an essential step in many data analysis pipelines due to its ability to remove unimportant data. We will describe how to realize a data set as a network using correlation, partial correlation, heat kernel and random edge generation methods. Then we lay out how to select features from these networks mainly leveraging the spectrum of the graph Laplacian, adjacency, and supra-adjacency matrices. We frame this work in the context of gene co-expression network analysis and proceed with a brief analysis of a small set of gene expression data for human subjects infected with the flu virus. We are able to distinguish two sets of 14-15 genes which produce two fold SSVM classification accuracies at certain times that are at least as high as classification accuracies done with more than 12,000 genes.
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Subject
feature selection
Laplacian
spectral
influenza
centrality
network