CSU Home
    • Login
    View Item 
    •   Mountain Scholar Home
    • Colorado State University, Fort Collins
    • CSU Theses and Dissertations
    • 2017- CSU Theses and Dissertations
    • View Item
    •   Mountain Scholar Home
    • Colorado State University, Fort Collins
    • CSU Theses and Dissertations
    • 2017- CSU Theses and Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Oncofetal proteins regulate proliferation and differentiation in placental cells

    Thumbnail
    Citable Link(s)
    https://hdl.handle.net/10217/191482
    Download/View
    West_colostate_0053A_15084.pdf (2.549Mb)
    View full record
    Altmetrics
    Abstract
    The chromatin associated transcription factor HMGA2 is a downstream target of let-7 miRNAs and binds to chromatin to regulate gene expression, inducing rapid cell proliferation during embryogenesis. Inhibition of let-7 miRNAs by RNA binding proteins LIN28A and LIN28B is necessary during early embryogenesis to ensure stable expression of HMGA2 and proper cell proliferation. In addition to LIN28, HMGA2 is regulated by a BRCA1/ZNF350/CtIP repressor complex. In normal tissues, the BRCA1/ZNF350/CtIP complex binds to the HMGA2 promoter to prevent transcription. However, in many cancers the oncomiR ...
    (For more, see "View full record.")
    Author(s)
    West, Rachel Claire

    Advisor(s)
    Winger, Quinton; Bouma, Gerrit

    Date Submitted
    2018
    Collections
    • 2017- CSU Theses and Dissertations
    • Theses and Dissertations - Biomedical Sciences

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
    HTML Sitemap  

     

    Browse

    All of Mountain ScholarCommunities & CollectionsDatesAuthorsTitlesSubjectsThis CollectionDatesAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
    HTML Sitemap