Cold-induced behavioral thermoregulation and energy metabolism in aging rats
Rapid senescence in aging F344 rats is marked by spontaneous rapid body weight loss, decreased food intake, altered circadian rhythms of core temperature, and severe cold-induced hypothermia near the end of life. This study tested the hypothesis that bahavioral thermoregulation remains intact in senescence and that selection of warm zones in a thermal gradient permits passive re-warming from cold-induced hypothermia, reducing the need for increased metabolic heat production. Longitudinal studies were performed on male F344 rats beginning at age 19 to 22 mos. Tests were performed every three weeks ...
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