Next generation antibiotics: progress toward the synthesis of an enzyme-activated nitric oxide-releasing fluorescent prodrug
Bacterial resistance to antibiotics is spreading at an alarming rate, and without the development of new antibiotics, common infections will become deadly. The goal of this project is to synthesize an enzyme-activated antibiotic prodrug that detects and kills bacteria. The antibiotic will incorporate nitric oxide, a known antibacterial agent, and a fluorescent compound to visualize bacterial presence. A synthesis procedure was developed to synthesize a fluorescent compound attached to a small signaling compound. A nitric oxide donor will be added in the future. In the presence of bacteria, the ...
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Hibbard, Hailey A. J.; Reynolds, Melissa M.