Investigation of mechanisms of mitotic recombination in yeast
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At the submicroscopic level within all living cells the workings of a dynamic molecular world attempt to preserve the integrity of DNA - the blueprint of life. This dissertation describes in detail the experimental systems and results from two of our studies conducted in which DNA lesions compromised genomic integrity. The unifying theme of the following chapters revolves around the mechanisms responsible for structural genomic variation, that is, what happens to chromosomes when they break. In the first phase of research, we examined outcomes associated with double-strand breaks (DSBs) at ...