Hypothalamic concentration of kisspeptin and GnRH during breeding season (BS) and non breeding season (NBS) in sheep
The kisspeptin system has emerged as an important regulator of mammalian reproduction. In ewes, kisspeptin neurons are located in specific hypothalamic regions such as the preoptic area (POA) and medio-basal hypothalamus (MBH) which include the arcuate nucleus (ARC). A specific radioimmunoassay (RIA) for the quantification of hypothalamic kisspeptin was developed to test the hypothesis that estradiol decreases the production of kisspeptin during the NBS in the MBH in addition to other forebrain areas that harbor kisspeptin neurons and/or axons such as the POA, the anterior hypothalamic area ...
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