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dc.contributor.advisorChong, Edwin K. P.
dc.contributor.authorDamale, Pranav
dc.date.accessioned2016-01-11T15:13:50Z
dc.date.available2016-01-11T15:13:50Z
dc.date.submitted2015
dc.identifierDamale_colostate_0053N_13325.pdf
dc.identifier.urihttp://hdl.handle.net/10217/170354
dc.descriptionIncludes bibliographical references.
dc.description2015 Fall
dc.description.abstractGait deficits are important clinical symptoms of Parkinson's disease (PD). Data focusing on gait can be used to measure recovery of motor impairments in rodents with systemic dopamine depletion. This thesis presents a design for a gait acquisition and analysis system able to capture paw strikes of a mouse, extract their positions and timing data, and report quantitative gait metrics to the operator. These metrics can then be used to evaluate the gait changes in mice. This work presents the design evaluation of the system, from initial cellphone captured video concepts through prototyping and testing to the final implementation. The system utilizes a GoPro camera, optimally lit walkway design, image processing techniques to capture footfalls, and algorithms for their quantitative assessment. The results gained from live animal study with methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and treated with 1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane (C-DIM12) are presented, and it is shown how the quantitative measurements can be used to determine healthy, injured, and recovering gait.
dc.languageEnglish
dc.language.isoeng
dc.publisherColorado State University. Libraries
dc.rightsCopyright of the original work is retained by the author.
dc.subjectC-DIM 12
dc.subjectimage processing
dc.subjectmouse gait
dc.subjectMPTP
dc.subjectobject detection
dc.subjectParkinson's disease
dc.titleDesign of a gait acquisition and analysis system for assessing the recovery in a classical murine model of Parkinson's disease
dc.typeThesis
dc.contributor.committeememberTjalkens, Ronald
dc.contributor.committeememberEbert-Uphoff, Imme
thesis.degree.nameMaster of Science (M.S.)
thesis.degree.levelMasters
thesis.degree.disciplineElectrical and Computer Engineering
thesis.degree.grantorColorado State University


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